How does iDimerize technology work? A chemical inducer of dimerization, or “dimerizer”, is a cell-permeant organic small molecule with two separate motifs that each bind with high affinity to a specific protein module (Dmr domain) fused onto the protein(s) of interest

The Reverse Dimerization System incorporates a binding motif (purple) that causes protein aggregation and a dimerizer (yellow) which can be used to disaggregate (solubilize) the proteins

Inducible secretion of proteins

Secretion of DmrD-tagged luciferase after addition of D/D Solubilizer