COVID-19 publications
Our customers and collaborators continue to make inroads in our understanding of SARS-CoV-2 using a broad range of scientific techniques. Cited below are selected studies in which our products and technologies were utilized to advance this research.
Publications grouped by application
Cloning
| Title | Link | Product |
|---|---|---|
| Cloning | ||
| Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses |  |
In-Fusion technology |
| Cross-reactive Antibody Response between SARS-CoV-2 and SARS-CoV Infections | |
In-Fusion HD Cloning Kit |
| Development of CRISPR as an Antiviral Strategy to Combat SARS-CoV-2 and Influenza | |
In-Fusion technology, Stellar chemically competent cells |
| Stability of RNA sequences derived from the coronavirus genome in human cells | |
In-Fusion HD technology |
| Cloning of ACE2 isoforms | ||
| The heterogeneous nature of the Coronavirus receptor, angiotensin-converting enzyme 2 (ACE2) in differentiating airway epithelia | |
In-Fusion SMARTer Directional cDNA Library Construction kit |
Lentiviral titration
| Title | Link | Product |
|---|---|---|
| Lentiviral titration (pseudovirus assay) | ||
| A high throughput screen for TMPRSS2 expression identifies FDA-approved and clinically advanced compounds that can limit SARS-CoV-2 entry | |
Lenti-X GoStix Plus |
| Nanoluciferase complementation-based biosensor reveals the importance of N-linked glycosylation of SARS-CoV-2 Spike for viral entry | |
Lenti-X GoStix Plus |
| Natural Killer cell activation, reduced ACE2, TMPRSS2, cytokines G-CSF, M-CSF and SARS-CoV-2-S pseudovirus infectivity by MEK inhibitor treatment of human cells | |
Lenti-X p24 Rapid Titer Kit |
Protein purification
| Title | Link | Product |
|---|---|---|
| Protein purification | ||
| A rapid, point of care red blood cell agglutination assay for detecting antibodies against SARS-CoV-2 | |
Capturem His-Tagged Purification Miniprep Kit |
| Dynamics of neutralizing antibody titers in the months after SARS-CoV-2 infection | |
TALON resin |
| Functional SARS-CoV-2-specific immune memory persists after mild COVID-19 | |
TALON resin |
| Pre-existing and de novo humoral immunity to SARS-CoV-2 in humans | |
TALON resin |
| SARS-CoV-2 and bat RaTG13 spike glycoprotein structures inform on virus evolution and furin-cleavage effects | |
TALON resin |
| Structural characterisation of a nanobody derived from a naïve library that neutralises SARS-CoV-2 | |
TALON resin |
| Ultra-sensitive high-resolution profiling of anti-SARS-CoV-2 antibodies for detecting early seroconversion in COVID-19 patients | |
TALON resin |
RNA-seq
| Title | Link | Product |
|---|---|---|
| Single-cell RNA-seq | ||
| A method to identify respiratory virus infections in clinical samples using next-generation sequencing | |
SMARTer Stranded RNA-Seq Kit |
| Defining the pandemic at the state level: sequence-based epidemiology of the SARS-CoV-2 virus by the Arizona COVID-19 Genomics Union (ACGU) | |
SMART-Seq Stranded Kit |
| Stranded RNA-seq | ||
| Complete genome sequence of a SARS-CoV-2 strain isolated in northern Germany | |
SMARTer Stranded Total RNA-Seq Kit v2 - Pico Input Mammalian |
| European context of the diversity and phylogenetic position of SARS-CoV-2 sequences from Polish COVID-19 patients | |
SMART-Seq Stranded Kit |
| Genomic epidemiology of SARS-CoV-2 in Guangdong Province, China | |
SMARTer Stranded Total RNA-Seq Kit v2 - Pico Input Mammalian |
| Genomics functional analysis and drug screening of SARS-CoV-2 | |
SMARTer Stranded Total RNA-Seq Kit v2 - Pico Input Mammalian |
| SARS-CoV-2 infection of human iPSC-derived cardiac cells predicts novel cytopathic features in hearts of COVID-19 patients | |
SMARTer Stranded Total RNA-Seq Kit v2 - Pico Input Mammalian |
| Transcriptomic similarities and differences in host response between SARS-CoV-2 and other viral infections | |
SMARTer Stranded Total RNA-Seq Kit v2 - Pico Input Mammalian |
| Ultra-low input RNA-seq | ||
| Association of respiratory allergy, asthma, and expression of the SARS-CoV-2 receptor ACE2 | |
SMART-Seq v4 Ultra Low Input RNA Kit |
| Baricitinib treatment resolves lower-airway macrophage inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques | |
SMART-Seq v4 Ultra Low Input RNA Kit |
| Coronavirus disease (COVID-19) and fertility: viral host entry protein expression in male and female reproductive tissues | |
SMART-Seq v4 Ultra Low Input RNA Kit |
| Expression of ACE2 and a viral virulence-regulating factor CCN family member 1 in human iPSC-derived neural cells: implications for COVID-19-related CNS disorders | |
SMART-Seq v4 Ultra Low Input RNA Kit |
| Functional SARS-CoV-2-specific immune memory persists after mild COVID‑19 | |
SMART-Seq v4 Ultra Low Input RNA Kit |
| Human iPSC-derived cardiomyocytes are susceptible to SARS-CoV-2 infection | |
SMART-Seq v4 Ultra Low Input RNA Kit |
| SARS-CoV-2 infection and replication in human fetal and pediatric gastric organoids | |
SMART-Seq v4 Ultra Low Input RNA Kit |
RT-qPCR
| Title | Link | Product |
|---|---|---|
| One-step RT-qPCR applications | ||
| A novel coronavirus from patients with pneumonia in China, 2019 | |
One Step PrimeScript RT-PCR Kit (Perfect Real Time) |
| Stability of RNA sequences derived from the coronavirus genome in human cells | |
PrimeScript RT Master Mix (Perfect Real Time) |
| A new coronavirus associated with human respiratory disease in China | |
One Step PrimeScript RT-PCR Kit (Perfect Real Time) |
| A novel protein drug, Novaferon, as the potential antiviral drug for COVID-19 | |
One Step PrimeScript RT-PCR Kit (Perfect Real Time) |
| A sensitive and affordable multiplex RT-qPCR assay for SARS-CoV-2 detection | |
One Step PrimeScript III RT-PCR Kit |
| A valid protective immune response elicited in rhesus macaques by an inactivated vaccine is capable of defending against SARS-CoV-2 infection | |
One Step PrimeScript RT-PCR Kit (Perfect Real Time) |
| In vitro antiviral activity and projection of optimized dosing design of hydroxychloroquine for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) | |
One Step PrimeScript RT-PCR Kit (Perfect Real Time) |
| Comparison of SARS-CoV2 N gene real-time RT-PCR targets and commercially available mastermixes | |
One Step PrimeScript III RT-PCR Kit |
| Detection of SARS-CoV-2 in pets living with COVID-19 owners diagnosed during the COVID-19 lockdown in Spain: A case of an asymptomatic cat with SARS-CoV-2 in Europe | |
One Step PrimeScript RT-PCR Kit (Perfect Real Time) |
| Functional mapping of B-cell linear epitopes of SARS-CoV-2 in COVID-19 convalescent population | |
One Step PrimeScript RT-PCR Kit (Perfect Real Time) |
| Heat inactivating and reusing of virus-contaminated disposable medical mask | |
One Step PrimeScript RT-PCR Kit (Perfect Real Time) |
| Search for SARS-CoV-2 inhibitors in currently approved drugs to tackle COVID-19 pandemia | |
PrimeScript RT Reagent Kit (Perfect Real Time) |
| Brief comparative evaluation of six open one-step RT-qPCR mastermixes for the detection of SARS-CoV-2 RNA using a Taqman probe | |
One Step PrimeScript RT-PCR Kit (Perfect Real Time) |
| Extraction-free SARS-CoV-2 detection by rapid RT-qPCR universal for all primary respiratory materials | |
PrimeDirect Probe RT-qPCR Mix |
| A thermostable mRNA vaccine against COVID-19 | |
One Step PrimeScript RT-PCR Kit (Perfect Real Time) |
| Effectiveness of 222-nm ultraviolet light on disinfecting SARS-CoV-2 surface contamination | |
One Step PrimeScript III RT-PCR Kit |
| Characteristics and early prognosis of COVID-19 infection in fracture patients | |
One Step PrimeScript RT-PCR Kit (Perfect Real Time) |
| GRL-0920, an indole chloropyridinyl ester, completely blocks SARS-CoV-2 infection | |
One Step PrimeScript III RT-PCR Kit |
| Community evidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission through air | |
PrimeScript One Step RT-PCR Kit Ver.2 |
| Comparison of saliva and nasopharyngeal swab SARS-CoV-2 RT-qPCR testing in a community setting | |
One Step PrimeScript III RT-PCR Kit |
| SARS-CoV-2 is restricted by zinc finger antiviral protein despite preadaptation to the low-CpG environment in humans | |
PrimeScript RT Reagent Kit (Perfect Real Time) |
| Detection of SARS-CoV-2 in wastewater in Japan during a COVID-19 outbreak | |
One Step PrimeScript RT-PCR Kit (Perfect Real Time) |
| Robust and persistent SARS-CoV-2 infection in the human intestinal brush border expressing cells | |
One Step PrimeScript III RT-PCR Kit |
| Identifying the risk of SARS-CoV-2 infection and environmental monitoring in airborne infectious isolation rooms (AIIRs) | |
One Step PrimeScript RT-PCR Kit (Perfect Real Time) |
| A SARS-CoV-2 variant with the 12-bp deletion at E gene | |
One Step PrimeScript RT-PCR Kit (Perfect Real Time) |
| RBD-Fc-based COVID-19 vaccine candidate induces highly potent SARS-CoV-2 neutralizing antibody response | |
One Step PrimeScript RT-PCR Kit (Perfect Real Time) |
| Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records | |
One Step PrimeScript RT-PCR Kit (Perfect Real Time) |
| Development and evaluation of a rapid and simple diagnostic assay for COVID-19 based on loop-mediated isothermal amplification | |
One Step PrimeScript III RT-PCR Kit |
| SARS-CoV-2 clearance in COVID-19 patients with Novaferon treatment: A randomized, open-label, parallel-group trial | |
One Step PrimeScript RT-PCR Kit (Perfect Real Time) |
| An open-label, randomized trial of the combination of IFN-κ plus TFF2 with standard care in the treatment of patients with moderate COVID-19 | |
One Step PrimeScript RT-PCR Kit (Perfect Real Time) |
| CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells | |
One Step PrimeScript RT-PCR Kit (Perfect Real Time) |
| Recovering coronavirus from large volumes of water |
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| Contamination-free visual detection of SARS-CoV-2 with CRISPR/Cas12a: A promising method in the point-of-care detection | |
One Step PrimeScript RT-PCR Kit (Perfect Real Time) |
| Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease | |
One Step PrimeScript RT-PCR Kit (Perfect Real Time) |
| A mouse model of SARS-CoV-2 infection and pathogenesis |
|
One Step PrimeScript RT-PCR Kit (Perfect Real Time) |
| Antibody-like proteins that capture and neutralize SARS-CoV-2 | |
|
| Role of neutrophil chemoattractant CXCL5 in SARS-CoV-2 infection-induced lung inflammatory innate immune response in an in vivo hACE2 transfection mouse model | |
One Step PrimeScript RT-PCR Kit (Perfect Real Time) |
| Newly identified viral genomes in pangolins with fatal disease | |
One Step PrimeScript RT-PCR Kit (Perfect Real Time) |
| Pathogenicity of porcine deltacoronavirus (PDCoV) strain NH and immunization of pregnant sows with an inactivated PDCoV vaccine protects 5‐day‐old neonatal piglets from virulent challenge | |
One Step PrimeScript RT-PCR Kit (Perfect Real Time) |
| Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection | |
One Step PrimeScript RT-PCR Kit (Perfect Real Time) |
| Beta- and novel delta-coronaviruses are identified from wild animals in the Qinghai-Tibetan Plateau, China | |
PrimeScript One Step RT-PCR Kit Ver.2 |
| Interleukin-1β modulation of the mechanobiology of primary human pulmonary fibroblasts: potential implications in lung repair | |
One Step PrimeScript RT-PCR Kit (Perfect Real Time) One-Step TB Green PrimeScript RT-PCR Kit II (Perfect Real Time) |
| SMARTScribe applications | ||
| ApharSeq: an extraction-free early-pooling protocol for massively multiplexed SARS-CoV-2 detection | |
SMARTScribe Reverse Transcriptase |
| Longitudinal isolation of potent near-germline SARS-CoV-2-neutralizing antibodies from COVID-19 patients | |
SMARTScribe Reverse Transcriptase |
| cDNA panels | ||
| A novel isoform of ACE2 is expressed in human nasal and bronchial respiratory epithelia and is upregulated in response to RNA respiratory virus infection | |
Human Cell Line MTC Panel |
Find more products for COVID-19 research
Helping researchers tackle COVID-19
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Hear how a Product Manager in Europe is adjusting to the changing research market in light of COVID-19.
Working hard to meet production demands for SARS-CoV-2 testing
Hear how a Takara Bio employee of 27 years is contributing to the COVID-19 effort.
Dethroning king coronavirus with novel vaccines
Find out which types of SARS-CoV-2 vaccines are out there and how Takara Bio is joining the fight.
COVID-19 drug discovery
Our hiPSC-derived cells and other cell biology research products help you study SARS-CoV-2 infection, identify potential targets for drug discovery, evaluate the metabolism and safety of candidate drugs, and develop therapeutic approaches for COVID-19.
Takara Bio products in COVID-19 publications
An ever-growing compilation of COVID-19 publications using Takara Bio products and technologies.
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