Immune profiling
Note: We are updating the names and formats of several of our NGS RNA-seq kits. Details of the changes are provided on the relevant product pages for these kits. You can find a complete list of kits with new names and the existing kits they will replace in the table below.
Immune profiling product reference guide with updated kit names and catalog numbers
| Existing kit name | Cat. # of existing kit | New kit name | Cat. # of new kit |
|---|---|---|---|
| 634478, 634479 | SMART-Seq Human TCR (with UMIs) | 634780, 634781, 634779 | |
| New product | SMART-Seq Human BCR (with UMIs) | 634777, 634778, 634776 |
Immune profiling involves the analysis of T- and B-cell receptors (TCRs/BCRs), which allow cells to bind specific antigens, proliferate, and then rapidly mount a specific immune response. We offer a variety of kits for T- and B-cell profiling of human (bulk BCR, bulk TCR, single-cell TCR) and mouse (bulk BCR, bulk TCR) samples to help researchers investigate immune cell development, examine mechanisms of autoimmune diseases and cancers, and develop models for immunotherapy of specific diseases.
Note: We are updating the names and formats of several of our NGS RNA-seq kits. Details of the changes are provided on the relevant product pages for these kits. You can find a complete list of kits with new names and the existing kits they will replace in the table below.
Immune profiling product reference guide with updated kit names and catalog numbers
| Existing kit name | Cat. # of existing kit | New kit name | Cat. # of new kit |
|---|---|---|---|
| 634478, 634479 | SMART-Seq Human TCR (with UMIs) | 634780, 634781, 634779 | |
| New product | SMART-Seq Human BCR (with UMIs) | 634777, 634778, 634776 |
Immune profiling involves the analysis of T- and B-cell receptors (TCRs/BCRs), which allow cells to bind specific antigens, proliferate, and then rapidly mount a specific immune response. We offer a variety of kits for T- and B-cell profiling of human (bulk BCR, bulk TCR, single-cell TCR) and mouse (bulk BCR, bulk TCR) samples to help researchers investigate immune cell development, examine mechanisms of autoimmune diseases and cancers, and develop models for immunotherapy of specific diseases.
Our kits streamline sample preparation by combining our SMART (Switching Mechanism at 5' End of RNA Template) technology with 5' RACE to capture V(D)J sequences, starting from RNA samples. Unlike methods that use DNA as a template, our kits identify expressed receptor sequences and provide greater sensitivity for a more comprehensive identification of unique functional variants. By avoiding multiplexed PCR reactions, these kits also give reproducible, sensitive, and unbiased results from a wide range of input amounts. Learn more about the kits and see sample data by viewing our tech notes.
Benefits
- Sensitive: detect rare functional variants
- Reproducible: consistent clonotype identification and isotype calling across a range of sample inputs
- Specific: optimized RACE-based PCR efficiently captures target region
- Illumina-ready: sequencing libraries can be multiplexed with up to 96 primer index options
SMART-Seq Human TCR (with UMIs)
SMART-Seq Human TCR (with UMIs) has optimized chemistry, UMIs, and UDIs for more accurate, reliable clonotype calling and quantification.
Products
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