Human stem cell-derived intestinal epithelial cells

Learn more about how Cellartis Intestinal Epithelial Cells (from ChiPSC18) and how they can improve your research

Note: this is a made-to-order product with a lead time and a minimum order quantity. Please inquire.

Cellartis Intestinal Epithelial Cells (from ChiPSC18) are small intestinal epithelial cells derived from human iPS cells. These cells have intestinal epithelial cell-like characteristics, including the ability to form tight junctions and the expression of villin and the intestinal transcription factor CDX2. In addition, the cells have higher expression of the metabolic enzyme CYP3A4 and transporter PEPT1 compared to the human colon cancer Caco-2 cell line.

Note: this is a made-to-order product with a lead time and a minimum order quantity. Please inquire.

The Cellartis Intestinal Epithelial Cells (from ChiPSC18) Kit consists of a frozen vial of Cellartis Intestinal Epithelial Cells (from ChiPSC18) and the Cellartis IEC Maturation Kit, which contains basal medium and supplements that are necessary for the cells' maturation. After thawing, Cellartis Intestinal Epithelial Cells (from ChiPSC18) can be used for various assays after a 5-day pre-cultivation using the included Cellartis IEC Maturation Kit.

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Cat. #

Product

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Price

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Quantity

Details

Y50035

Cellartis® Intestinal Epithelial Cells (from ChiPSC18) Kit

1 Kit

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License Statement

ID Number
L67	This product is covered by one or more claims of the issued patents and pending patent applications: U.S. Patent Nos. 8,048,999, 8,058,065, 8,129,187, 8,211,697, 8,257,941, 8,278,104, 8,530,238, 8,900,871, 8,927,277, 8,951,801, 9,213,999, 9,404,124, 9,499,797, 9,677,141, 9,714,433, and 9,938,585 and foreign counterparts thereof, including their divisions, continuations, extensions, substitutions, and those claiming priority therefrom or those claiming the same priorities therein. This Product is manufactured and sold by Takara Bio Inc. and/or its affiliate(s) based on a patent license from iPS Academia Japan, Inc. No express or implied license is granted to the purchaser. "Product" means the differentiated cells manufactured and sold by Takara Bio Inc. "Internal research purpose" means the use of this Product as a tool of internal research for the sole benefit of the purchaser or purchaser's contract research customer, (including screening of compounds, antibodies, proteins, peptides and others in developing pharmaceuticals (including diagnostic agents) for human and/or animal use), provided, however, that the following activities using this Product are strictly prohibited and expressly excluded from Internal research purposes: With the exemption for academic and non-commercial clinical research done by non-profit institutions; 1) Administration of this Product to humans. 2) Use of this Product for the diagnostic testing, prevention, or treatment of human and/or animal diseases. 3) Use of this Product in studies involving administration to humans for cell therapy, regenerative medicine etc. Purchaser may use this Product for its own Internal research purposes. Purchaser shall not use the Products for its commercial purposes. Notwithstanding the foregoing, the purchaser of this Product may provide third parties with contract research services by using this Product only for such third party's Internal research purposes.
C007	This product is manufactured and sold by Takara Bio Inc. and/or its affiliate(s) (“Takara”) under a license from ViaCyte Inc. (“ViaCyte”). This product is covered by one or more claims of patents owned by ViaCyte, including WO2005063971, WO2006017134, WO2006071911, WO2005116073 and WO200616999, and their foreign counterparts. The use of this product is strictly limited to purchaser's own internal research. Purchaser has no right to use this product or its components in humans for any purposes including but not limited to diagnostics, therapeutics, or clinical trials. Purchaser has no right to resell or transfer this product to a third party regardless of whether or not compensation is received. Purchasers wishing to use this product for purposes other than internal research use should contact Takara. No express or implied license is granted to the purchaser.
L72	This product is manufactured and sold by Takara Bio Inc. based on a license to Cellectis SA. The use of this product is strictly limited to purchaser's own internal research, including basic research, drug discovery research up to and including IND-enabling preclinical toxicological studies or equivalents thereof, excluding any use in the T-cell field. Purchaser cannot have any right to use this product or its components in humans for any purposes including but not limited to diagnostics and/or therapeutics, or otherwise clinical trials. Purchase does not include any right to resell or transfer this product to a third party regardless of whether or not compensation is received. Purchasers wishing to use this product for purposes other than internal research use should contact us. No express or implied license is granted to the purchaser.
L79	This product is covered by the claims of pending applications WO2020/262492.

Note: This is a made-to-order product with a lead time and a minimum order quantity. Please inquire.

Cellartis Intestinal Epithelial Cells (from ChiPSC18) are small intestinal epithelial cells derived from human induced pluripotent stem (hiPS) cells. This product includes the following items: one frozen vial of Cellartis Intestinal Epithelial Cells (from ChiPSC18) and one Cellartis IEC Maturation Kit.

Notice to purchaser

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.

Components

*You must be logged in to a Purchasing Account in order to purchase these products online, since the purchase of these products may be restricted depending on your account type. Researchers at not-for-profit accounts receive a limited use license with their purchase of the product. Researchers at for-profit accounts must obtain a license prior to purchase. For details please contact licensing@takarabio.com.

Overview

Cells form tight junctions within 5 days of thawing and can be used on Days 5–8 post-thaw
Cells express intestinal markers (e.g., villin and CDX2) at high levels
Drug metabolizing enzyme CYP3A4 and drug transporter PEPT1 are expressed at high levels compared to Caco-2 cells
Cells form a functional, permeable barrier that can be used to predict in vivo drug permeability and absorption

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Applications

Evaluation of drug absorption and metabolism in the small intestine
ADME profiling in drug discovery
Drug permeability assays

Components

1 vial of ~ 4.8 x 10⁶ cells
1 Cellartis IEC Maturation Kit
- IEC Maturation Basal Medium
- IEC Supplement A
- IEC Supplement B
- IEC Supplement C
- IEC Supplement D

Additional information
Please see the product's Certificate of Analysis for information about storage conditions, product components, and technical specifications. Please see the Kit Components List to determine kit components. Certificates of Analysis and Kit Components Lists are located under the Documents tab.

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Human stem cell-derived intestinal epithelial cells

Notice to purchaser

Components of the Cellartis Intestinal Epithelial Cells (from ChIPSC18) Kit

Immunostaining of tight junction protein ZO-1

Expression of the intestinal epithelial markers villin and CDX2

Expression of drug metabolizing enzyme CYP3A4 and drug transporter PEPT1 mRNAs

Overview

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