Advances in Genome Biology and Technology
Discover more with spatial genomics solutions and long-read mRNA-seq technologies for ultra-low inputs
The Advances in Genome Biology and Technology (AGBT) General Meeting brought together top global researchers, leaders, and innovators. Significant scientific advances were announced and showcased, and partnerships between science and industry were forged. Through our poster presentations, we shared our latest innovations for spatial genomics and long-read (LR) mRNA-seq from ultra-low inputs (~10 pg to 100 ng total RNA) such as precious clinical samples.
Poster presentations
Enabling long-read mRNA-seq for biomarker discovery using limited clinical sample inputs
With this poster, Dr. Yue Yun presented data from a new long-read RNA sequencing product that enables full-length RNA sequencing from single cells (~10 pg) up to 100 ng total RNA. With a 10 ng total RNA input, we demonstrate the ability to reliably sequence at an average length (N50) of 2 kb and detect full-length transcripts as long as 10 kb. Performance at the single-cell level is substantially better than existing single-cell LR-RNA-seq methods. Furthermore, our data provides a more complete picture of isoform specific changes compared to other commercially available technologies. With the ability to process up to 96 samples at a time, this technology will enable the processing of rare or valuable samples to uncover novel biomarkers beyond gene expression.
Download PDFUnlocking multiomic analysis in spatial genomics: integrating spatial ATAC-seq and V(D)J sequencing with gene expression using novel spatial barcoding of single nuclei
In this poster, Dr. Christina Chang used Curio Trekker to transform single-cell sequencing assays into spatially resolved single-cell data. This technology utilizes unique DNA barcodes on a tightly packed bead array to spatially label individual cells. The resulting tagged nuclei are then processed on conventional single-cell sequencing platforms, preserving spatial information while providing true single-cell resolution. In this study, Curio Trekker was applied to achieve spatial ATAC-seq (Assay for Transposase-Accessible Chromatin using sequencing) combined with gene expression analysis, as well as spatial V(D)J sequencing paired with gene expression.
SMART-Seq® mRNA Long Read kits now available!
Long-read mRNA-seq
Generate high-quality, long-read, barcoded cDNA from 1–1,000 intact cells or 10 pg–100 ng of total RNA.
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