STEM121 antibody citation list

STEM121 antibody (formerly named SC121) is a mouse monoclonal antibody specific to human cytoplasm. It does not cross-react with mouse, rat, or monkey tissue. This human-specific antibody enables the quantification of engraftment, survival, migration, and differentiation of transplanted human stem cells in xenograft models. Read below for a citation list of studies in which STEM121 antibody was used in peer-reviewed basic, translational, preclinical, and biomedical research.

Cuenca, N. et al. Phagocytosis of photoreceptor outer segments by transplanted human neural stem cells as a neuroprotective mechanism in retinal degeneration. Invest. Ophthalmol. Vis. Sci. 54, 6745–56 (2013).

Cummings, B. J. et al. Human neural stem cells differentiate and promote locomotor recovery in spinal cord-injured mice. Proc. Natl. Acad. Sci. 102, 14069–14074 (2005).

Cummings, B. J., Uchida, N., Tamaki, S. J. & Anderson, A. J. Human neural stem cell differentiation following transplantation into spinal cord injured mice: association with recovery of locomotor function. Neurol. Res. 28, 474–81 (2006).

Eckert, A. et al. Bystander Effect Fuels Human Induced Pluripotent Stem Cell-Derived Neural Stem Cells to Quickly Attenuate Early Stage Neurological Deficits After Stroke. Stem Cells Transl. Med. 4, 841–51 (2015).

Gorris, R. et al. Pluripotent stem cell-derived radial glia-like cells as stable intermediate for efficient generation of human oligodendrocytes. Glia 63, 2152–2167 (2015).

Gowing, G. et al. Glial cell line-derived neurotrophic factor-secreting human neural progenitors show long-term survival, maturation into astrocytes, and no tumor formation following transplantation into the spinal cord of immunocompromised rats. Neuroreport 25, 367–72 (2014).

Gras Navarro, A. et al. NK cells with KIR2DS2 immunogenotype have a functional activation advantage to efficiently kill glioblastoma and prolong animal survival. J. Immunol. 193, 6192–206 (2014).

Guzman, R. et al. Long-term monitoring of transplanted human neural stem cells in developmental and pathological contexts with MRI. Proc. Natl. Acad. Sci. U. S. A. 104, 10211–6 (2007).

Haus, D. L. et al. CD133-enriched Xeno-Free human embryonic-derived neural stem cells expand rapidly in culture and do not form teratomas in immunodeficient mice. Stem Cell Res. 13, 214–26 (2014).

Hook, L. et al. Non-immortalized human neural stem (NS) cells as a scalable platform for cellular assays. Neurochem. Int. 59, 432–44 (2011).

Hooshmand, M. J. et al. Analysis of host-mediated repair mechanisms after human CNS-stem cell transplantation for spinal cord injury: correlation of engraftment with recovery. PLoS One 4, e5871 (2009).

Ishizaka, S. et al. Intra-arterial cell transplantation provides timing-dependent cell distribution and functional recovery after stroke. Stroke. 44, 720–6 (2013).

Kelly, S. et al. Transplanted human fetal neural stem cells survive, migrate, and differentiate in ischemic rat cerebral cortex. Proc. Natl. Acad. Sci. U. S. A. 101, 11839–44 (2004).

Lee, H. et al. Human fetal brain-derived neural stem/progenitor cells grafted into the adult epileptic brain restrain seizures in rat models of temporal lobe epilepsy. PLoS One 9, e104092 (2014).

Liu, C. et al. IQGAP1 suppresses TβRII-mediated myofibroblastic activation and metastatic growth in liver. J. Clin. Invest. 123, 1138–56 (2013).

Liu, C. et al. PDGF receptor-α promotes TGF-β signaling in hepatic stellate cells via transcriptional and posttranscriptional regulation of TGF-β receptors. Am. J. Physiol. Gastrointest. Liver Physiol. 307, G749–59 (2014).

Mattis, V. B. et al. Neonatal immune-tolerance in mice does not prevent xenograft rejection. Exp. Neurol. 254, 90–8 (2014).

McGill, T. J. et al. Transplantation of human central nervous system stem cells - neuroprotection in retinal degeneration. Eur. J. Neurosci. 35, 468–77 (2012).

Merkle, F. T. et al. Generation of neuropeptidergic hypothalamic neurons from human pluripotent stem cells. Development 142, 633–43 (2015).

Müller, J. et al. Intrastriatal transplantation of adult human neural crest-derived stem cells improves functional outcome in parkinsonian rats. Stem Cells Transl. Med. 4, 31–43 (2015).

Nasonkin, I. et al. Long-term, stable differentiation of human embryonic stem cell-derived neural precursors grafted into the adult mammalian neostriatum. Stem Cells 27, 2414–26 (2009).

Piltti, K. M. et al. Transplantation dose alters the dynamics of human neural stem cell engraftment, proliferation and migration after spinal cord injury. Stem Cell Res. 15, 341–53 (2015).

Piltti, K. M., Salazar, D. L., Uchida, N., Cummings, B. J. & Anderson, A. J. Safety of epicenter versus intact parenchyma as a transplantation site for human neural stem cells for spinal cord injury therapy. Stem Cells Transl. Med. 2, 204–16 (2013).

Piltti, K. M., Salazar, D. L., Uchida, N., Cummings, B. J. & Anderson, A. J. Safety of human neural stem cell transplantation in chronic spinal cord injury. Stem Cells Transl. Med. 2, 961–74 (2013).

Salazar, D. L., Uchida, N., Hamers, F. P. T., Cummings, B. J. & Anderson, A. J. Human neural stem cells differentiate and promote locomotor recovery in an early chronic spinal cord injury NOD-scid mouse model. PLoS One 5, e12272 (2010).

Sareen, D. et al. Human induced pluripotent stem cells are a novel source of neural progenitor cells (iNPCs) that migrate and integrate in the rodent spinal cord. J. Comp. Neurol. 522, 2707–28 (2014).

Shirai, H. et al. Transplantation of human embryonic stem cell-derived retinal tissue in two primate models of retinal degeneration. Proc. Natl. Acad. Sci. 113, 201512590 (2015).

Sontag, C. J. et al. Immunosuppressants affect human neural stem cells in vitro but not in an in vivo model of spinal cord injury. Stem Cells Transl. Med. 2, 731–44 (2013).

Sontag, C. J., Uchida, N., Cummings, B. J. & Anderson, A. J. Injury to the spinal cord niche alters the engraftment dynamics of human neural stem cells. Stem Cell Rep. 2, 620–32 (2014).

Tamaki, S. J. et al. Neuroprotection of host cells by human central nervous system stem cells in a mouse model of infantile neuronal ceroid lipofuscinosis. Cell Stem Cell 5, 310–9 (2009).

Tatarishvili, J. et al. Human induced pluripotent stem cells improve recovery in stroke-injured aged rats. Restor. Neurol. Neurosci. 32, 547–58 (2014).

Tornero, D. et al. Human induced pluripotent stem cell-derived cortical neurons integrate in stroke-injured cortex and improve functional recovery. Brain 136, 3561–77 (2013).

Uchida, N. et al. Human neural stem cells induce functional myelination in mice with severe dysmyelination. Sci. Transl. Med. 4, 155ra136 (2012).

Xu, L. et al. Transplantation of human oligodendrocyte progenitor cells in an animal model of diffuse traumatic axonal injury: survival and differentiation. Stem Cell Res. Ther. 6, 93 (2015).