Dentin matrix protein 1 detection
Dentin matrix protein 1 (DMP1) is an acidic extracellular matrix phosphoprotein that can bind calcium. DMP1 is required for bone and dentin mineralization and is expressed in the cells of bone and teeth. It is thought to play a role in regulating expression of osteoblast-specific genes during osteoblast cell differentiation and is localized to the nucleus in osteoblast precursor cells. In mature osteoblasts, the DMP1 protein is phosphorylated and localized to the extracellular matrix, where it plays a role in forming mineralized matrix. While other constitutively expressed proteins in the extracellular matrix, such as osteopontin and osteocalcin, are expressed in osteoblast cells, DMP1 is expressed in osteocytes, making it a candidate biomarker for osteocyte activity.
Dentin matrix protein 1 (DMP1) is an acidic extracellular matrix phosphoprotein that can bind calcium. DMP1 is required for bone and dentin mineralization and is expressed in the cells of bone and teeth. It is thought to play a role in regulating expression of osteoblast-specific genes during osteoblast cell differentiation and is localized to the nucleus in osteoblast precursor cells. In mature osteoblasts, the DMP1 protein is phosphorylated and localized to the extracellular matrix, where it plays a role in forming mineralized matrix. While other constitutively expressed proteins in the extracellular matrix, such as osteopontin and osteocalcin, are expressed in osteoblast cells, DMP1 is expressed in osteocytes, making it a candidate biomarker for osteocyte activity.
Alternative names: dentin matrix protein-1, dentin matrix protein-I, DMP1, DMP-1.
Antibody for dentin matrix protein 1 detection
Polyclonal Anti-Dentin Matrix Protein-I antibody is a rabbit polyclonal antibody raised against the KLH-conjugated peptide (90–111) derived from the N-terminus of rat DMP1. This antibody is intended for the detection of human, mouse, and rat DMP1.
Overview
| Antigen/peptide | Cat. # | Application | Species | (Clone) and source | Cross‑reactivity |
| Dentin matrix protein 1 (90–111) | M176 | IHC, WB | Rat | (n/a) Rabbit IgG PoAb KLH‑conjugated |
Cross-reacts with human and mouse dentin matrix protein 1 |
More Information
Please see the product's Certificate of Analysis for information about storage conditions, product components, and technical specifications. Please see the Kit Components List to determine kit components. Certificates of Analysis and Kit Components Lists are located under the Documents tab.
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