Biomarker and drug discovery

The introduction of targeted therapies for cancers and other diseases has revolutionized the healthcare field. However, many treatments still struggle with limited efficacy and increased resistance in patients. To succeed, therapeutics development must start with high-quality molecular profiling for accurate biomarker and drug target identification.

Due to the complexity of the cancer genome, researchers have increasingly applied next-generation sequencing (NGS) technologies to explore tumor heterogeneity at new depth, resolution, coverage, and throughput. From identifying noncoding RNA biomarkers to analyzing rare tumor subclones, discover how researchers are using powerful NGS techniques like whole-genome amplification (WGA) and total RNA sequencing to investigate disease pathogenesis and targetable therapeutic avenues.

Download our drug discovery infographic (below)! Fill out the form (left) to access additional resources on advancing biomarker discovery research.*

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CASE STUDY

Deconvoluting leukemic heterogeneity with single-cell whole-genome sequencing

In this case study, Dr. Ilaria Iacobucci from the St. Jude Children’s Research Hospital profiles human B-cell acute lymphoblastic leukemia (B-ALL) samples at single-cell resolution and unprecedented throughput with Shasta technology. Her successful characterization of leukemic heterogeneity reveals insights into B-ALL progression and future therapeutic development.

Coming soon

WHITE PAPER

Single-cell DNA sequencing in cancer: Applications, technologies, and challenges

EBOOK

Cancer drug discovery 101: Accelerating oncology research with single-cell genomics

Infographic: Identifying mutation targets for drug discovery 

Read our infographic for a roadmap of targeted therapy development, from early biomarker discovery to in vivo translational research.

Download a copy