Embgenix Analysis Software for Embgenix PGT-A Kit (RUO)
The Embgenix Analysis Software is a cloud-based software for the analysis of sequencing data generated using the Embgenix PGT-A Kit (RUO). The algorithm computes calculated copy numbers (CCNs) using bin counts against an internally configured reference to determine CNVs accurately. The software allows the option for both automated and/or manual calls for whole chromosome, segmental, and mosaic aneuploidies, and data can be conveniently visualized in a chart or an idiogram plot. The software also supports downloadable PDF reports, which can be customized for individual laboratory needs.
CNV plot from trophectoderm (TE) biopsy samples showing aneuploidy on chromosome 7. The sample was processed for whole genome amplification and NGS library prep using the Embgenix PGT-A Kit. Following sequencing, data analysis and visualization were performed using Embgenix Analysis Software.
Supported operating systems
- Windows OS: Version 7 and higher
- Mac OS: Sierra (Version 10.12) or higher
Hardware requirements
Any standard desktop or laptop with the following specifications are recommended:
- Memory: 8 GB RAM or higher
- Free disk space: 100 GB or higher hard drive space
- Connectivity: connection to a high-speed and reliable internet network for upload of input data
Additional third-party software dependencies
- Web browser: Google Chrome (preferred), Safari, or Microsoft Edge
- Access to Illumina MiSeq® or NextSeq® sequencing data, stored either on the user's computer or a mapped network drive
Required input files
- Single- or paired-end FASTQ files generated by an Illumina MiSeq or NextSeq system as part of the Embgenix PGT-A Kit
Embgenix PGT-A Kit (RUO)
The Embgenix PGT-A kit workflow has been optimized for detection of copy number variation (CNV) from gDNA or embryo TE samples for Illumina platforms.
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