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ICELL8 introduction
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Technical notes
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Next-generation sequencing
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RNA-seq
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Technotes
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Webinars
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Technical notes
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DNA-seq
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Immune Profiling
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DNA-seq
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DNA-seq protocols
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Webinars
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Stem cell research
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Gene editing in hiPS cells
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Protein research
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His-tag purification
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Protocols
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PCR
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Technical notes
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Cloning
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In-Fusion Cloning general information
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In-Fusion Cloning and competition
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Applications and technical notes
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Traditional molecular cloning
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Restriction enzyme overview
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Restriction enzyme overview
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Real-time PCR
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Technical notes
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Sign up to watch the webinar
Research highlight
TE-chimeric transcripts in cancer
Tumors comprise a heterogeneous landscape of cells, each with their own unique gene expression profile. To parse this tumor heterogeneity, cancer researcher Colin McCornack has used single-cell technology to explore the regulatory roles of transposable elements (TEs) in lung cancer cells.
Register for a guest webinar and spotlight about Colin's research on cancer dysregulation using TE-chimeric transcripts!*
If you are on a mobile device, click on the hamburger icon () on the top left of your screen, then scroll down to access the registration form.
Watch our interview with Colin to learn about his inspirations, roadblocks, and most exciting single-cell discoveries.
Meet the speaker
Colin McCornack is an MSTP student pursuing a PhD in Computational and Systems Biology at Washington University School of Medicine in St. Louis. He has recently joined the lab of Dr. Ting Wang, where his research focuses on the interaction between p53 and transposable elements, specifically in the context of epigenetic therapy. He will be presenting preliminary work on detecting different transcript isoforms in cancer cell lines.
Dive deeper into research from the Wang Lab about the co-opting of TEs as regulatory elements in cancer and identification of p53‑regulated biomarkers with high-throughput single-cell technologies. Fill out the form to access these resources!
Guest webinar: TE-chimeric transcripts in cancer: from bulk to single-cell
In this guest webinar, Colin speaks about his recent work on the co-opting of transposable elements as cis-regulatory elements in cancer, with a special emphasis on recent efforts to uncover expression at the single-cell level using the new Shasta Single Cell System.
Topics covered:
- Transposable elements (TEs) in homeostasis and disease
- Cancer dysregulation and roles of chimeric TEs
- Deep exploration of TE-chimeric transcript expression with Shasta Single Cell System
Research spotlight: lncRNA biomarkers identified in cancer cell line models utilizing the Shasta Total RNA-Seq Kit
In this research spotlight, Dr. Ting Wang and his team apply high-throughput, single-cell total RNA profiling to study transcriptional changes in human lung cancer cell lines and identify lncRNA biomarkers regulated by p53 or epitherapy.
Topics covered:
- Capturing lncRNAs and protein-coding genes with a random-priming based method
- Enabling high-throughput total RNA profiling scaling up to 100,000 single cells in 1–12 different samples
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